Background: There are many factors that affect quality of provided cardiopulmonary resuscitation, as it can improves return of spontaneous circulation and prevent sudden death. Aim: The present study was conducted to assess factors affecting performance of cardiopulmonary resuscitation team. Research design: A descriptive exploratory design. Setting: This study was conducted in Intensive Care Unit and Emergency Department of Wady El-Natroun Central Hospital. Subject: A convenient sample of all available nurses (N=55), and all available physicians (N=6). Tools: Three tools were developed (adapted) by the investigator to collect data and they were; cardiopulmonary resuscitation team knowledge assessment questionnaire, cardiopulmonary resuscitation quality assessment observational checklists and factors affecting cardiopulmonary resuscitation team performance checklists. Result: There was a statistical significant relationship between demographic characteristics (age of the studied subjects, education, years of experience and cardiopulmonary resuscitation training courses) regarding to total knowledge of the studied subjects, cardiopulmonary resuscitation teams' practice and factors affecting performance of cardiopulmonary resuscitation team. While there was a statistical significant relationship between total cardiopulmonary resuscitation teams' practice regarding to total knowledge of the studied subjects and factors affecting their performance.Conclusion: It was concluded that, several demographic factors were affecting the performance (age, years of experience, level of education and attendance of cardiopulmonary resuscitation courses), in addition to the organizational factors and personal factors. Also it was found that the knowledge level was affecting the performance. Recommendations: The study recommended the importance of implementing continuous training programs and recommended to obtain basic life support and advanced life support before practicing the profession.