Background: The visually impaired students are in need for continuous support in their personal activities. They are extremely vulnerable because of the limitation for accessing the health information. Aim: To evaluate the effect of Audio drama based educational program on healthy lifestyle practices among visually impaired students. Design: A quasi experimental pre/post-test research design. Setting: Al-Nour School for the Blind, Kafr El-Sheikh governorate. Sample: A purposive sample of 210 visually impaired students. Tool I: Healthy lifestyle reported practices interviewing questionnaire involved 3 parts; 1^st: Demographic data. 2^nd: Students' medical and family history. 3^rd: Visually impaired Students' reported lifestyle practices. Tool II: Students' satisfaction questionnaire regarding audio drama sessions. Results: Students' mean age was 11.25±3.1, 57.1% of visually impaired students were females, 68.6% live in rural areas. Visual impairment cause was congenital in 59.04% of them, followed by hereditary causes in 28.57%, 67.61% were obese. A statistically significant difference in students' reported lifestyle practices was shown between pre/post audio drama teaching program at (p <0.001) regarding all lifestyle domains of nutrition, physical activity, stress management, interpersonal relations, spiritual growth, personal hygiene, and sleep pattern. Conclusion: Using audio drama educational program was effective in improving the students' lifestyle reported practices. Recommendation: Generalization of the awareness and training programs regarding healthy lifestyle among the visually impaired students investing the benefits of audio drama.