Aim: This study assessed the effectiveness of an empowerment intervention program on discrimination and internalized stigma among patients with a diagnosis of schizophrenia. Design: A pre-post-test non- equivalent group design was used in this study. Setting: in-patient male departments in the Psychiatry and Addiction Prevention University Hospital. Sample: A purposive sample consisting of 30 patients diagnosed with schizophrenia was randomly assigned and divided into two groups (study and control groups). Tools: The current study gathered data using three tools: personal data sheet, an internalized stigma scale, and an amended apparent devaluation discrimination scale. Results: At baseline, there were statistically significant differences between the control group and the internalized stigma total (p=0.003) and subscales alienation (p=0.001), stereotype endorsement (p=0.009), and perceived discrimination (p=0.023). With patients with a diagnosis of schizophrenia, the empowerment intervention sessions significantly reduced internalized stigma and revised perceived devaluation discrimination, resulting in lower mean internalized stigma and revised perceived devaluation discrimination scores for the study group compared to the control group. The Revised Perceived Devaluation Discrimination also decreased significantly after the empowerment intervention program (p= 0.001).Conclusion: This study indicated that the empowering intervention was effective when it is integrated with treatment as usual.