Dyspnea and a higher volume of secretions are common complaints among chronic obstructive
pulmonary disease patients. As a result, there is a current tendency to adopt non-pharmacological
approaches to help clear secretions, improve lung function, and relieve dyspnea. So, the aim of this
research was to evaluate the effect of autogenic drainage and acupressure on the respiratory
outcomes of non-invasive mechanically ventilated COPD patients. A quasi-experimental design was
used. Setting: chest and general intensive care units at Assuit University Hospitals. Sixty non-
invasive mechanically ventilated COPD patients recently admitted were included. Data was
collected using two tools: tool I: patient assessment sheet, tool II respiratory outcome assessment
sheet. Results: There was a highly significant reduction in the respiratory rate in study group after
application of autogenic drainage and acupressure at 3rd and 7th day (p < 0.001), significance
differences were found regarding PaO2, SaO2 before and after intervention between study and
control groups at 7th day with P. value (0.004, 0.029and 0.005&0.005)respectively. Moreover, there
was highly significance increase in the amount of sputum clearance at 7th day (p < 0.001),
improvement with highly significance in dyspnea measures among study group patients 7th day
(p < 0.005) after extubation and (p < 0.001) before discharge. Conclusion: applying autogenic
drainage and acupressure had statistically significant positive effect on respiratory parameters
outcomes on non invasive mechanically ventilated COPD Recommendations: provide educational
program for nurses about AD and acupressure.