Background: Emergency situation is a sudden onset event that disrupts the functioning of the facility and endangering patients, staff, and visitors. Nurses are well positioned to serve in leadership roles within health care agencies during times of emergency. Planning for a successful emergency response is essential to ensuring the best possible outcome for all parties involved. The aim: This study aimed to consolidate knowledge and practice of head and charge nurses regarding emergency situations in hospital. Setting: The study was conducted in Beni-Suef university Hospital. Research designs: Quazi – experimental design. Subjects: A convenience 70 head and charge nurses.  Tools:  three tools were used (I) A questionnaire for participants' demographic characteristics format, (II) knowledge assessment questionnaire and (III) observation checklist for practice. Results: The study finding showed that statistically significant differences were detected regarding all items of emergency situations management (P< 0.001). The majority of subjects' knowledge had satisfied by high score average 90% - 95.7% after implemented  program There is a highly statistically difference among the three practice procedures, pre and post the educated program as (p < 0.001) and there was improvement in their practice after implemented program  by percent of 90%.  Conclusion: It is concluded that the overall participants' knowledge and practice regarding emergency situations management were satisfactory after implemented program Recommendations: Hospital administration should develop training programs for all categories of nursing staff regarding emergency situations management and conduct drills to ensure competence of staff in emergency situation at least once yearly.