Background: The placental stage of labor occurs between the completion of the newborn's
delivery and the completion of the placenta's delivery. Aim: To evaluate the effectiveness of
placental stage of labor care protocol on performance of maternity nurses in Port Said city. Design:
A quasi-experimental design was used. Setting: The current study was performed in the labor and
delivery departments of two hospitals in Port Said: Obstetrics and Gynecological Specialized
Hospital and Alhayaa Hospital. Subjects: A total of 48 nurses were selected convenience for the
intervention part of this study. Tools: Structured Self -administered questionnaire and an
observational checklist were used to collect data. Results: In the pre-test, more than two thirds of
the studied nurses had an unsatisfactory level of knowledge and practices regarding caring of
women during the placental stage of labor, but in the post-test and follow-up tests, the highest
percentage of the nurses had a satisfactory level of knowledge and practices. Also, there was a
highly statistically significant positive correlation between nurses' knowledge and practice about
caring of women during placental stage of labor at pre-post and follow-up of developed nursing
protocol implementation. Conclusion: The placental stage of labor care protocol had a highly
statistically significant positive impact on the studied maternity nurses' performance regarding
caring of women during the placental stage of labor. Recommendations: Availability of the
developed care protocol and creating a standardized guideline for different services to follow in
order to sustain and provide high-quality health care for women during the third stage of labor.