Background: Early detection and prevention of preeclampsia (PE) are very important to avoid
morbidity and mortality associated with them. Recent efforts have focused on the selection of high
risk women and increasing their awareness and compliance with effective interventions as early as it
is possible. Aim: This study aimed to assess the effect of guided instructions using bundle of care
on knowledge and compliance with treatment among pregnant women high risk for preeclampsia.
Design: A quasi-experimental design was utilized in this study. Setting: This study was carried out
at the antenatal outpatient clinics of Mansoura University Hospitals, Egypt. Study subjects: Anon
probability purposive sample of 108 pregnant women was allocated either to the control group who
received the routine antenatal care and the intervention group who received preeclampsia bundle of
care intervention. Tools: A structured interview questionnaire to cover data related to general
characteristics and obstetric history; pregnant women knowledge regarding preeclampsia
questionnaire and compliance with preeclampsia treatment questionnaire. Results: The present
study results showed that there was a highly statistical significant increase (p < 0.001) in total
knowledge score post intervention compared to pre intervention among pregnant women in both
groups and a statistical significant increase in total score of pregnant women compliance with
preeclampsia treatment in the intervention group compared to the control group post-intervention (
p < 0.05), only (27.8%) of women in the intervention group compared to half (50%) in the control
group developed preeclampsia with statistical significant difference among both groups ( p < 0.05).
Conclusion: The current study hypothesis were accepted where applying guided instructions using
bundle of care was an effective intervention for improving knowledge and compliance with
treatment among pregnant women high risk for preeclampsia in the intervention group compared to
the control group. Recommendation: The current study recommended integrating guided
instructions using bundle of care as a nursing intervention into the routine antenatal care in the
study setting.