Background: Recent changes in the labor market have brought increased attention to work alienation and job security among both scholars and professionals. Aim: This study aimed to examine job security as perceived by staff nurses and its relation to their work alienation. Design: The study utilized a descriptive, correlational design. Setting: The research was conducted at the Pediatric Hospital affiliated with Ain Shams University Hospitals. Subjects: The sample consisted of 137 randomly selected staff nurses from a total of 210: Tools of data collection: Data were collected using two instruments: the Job Security Scale and the Work Alienation Scale. Results: The results indicated that over half of the staff nurses had a moderate perception of job security, while less than half experienced a moderate level of work alienation. Conclusion:  The study concluded that there is a statistically significant negative correlation between the nurses' perception of job security and their level of work alienation. Recommendations: The study recommends creating a supportive work environment to reduce feelings of powerlessness and meaninglessness, including leadership training for managers to enhance team support and provide opportunities for nurses to engage in meaningful work.