Background: Patient safety has become a priority in health policy and healthcare
management. Staff nurses play a vital role in improving the safety and quality of patient care in the
hospital. Aim of the study: to assess challenges facing staff nurses to maintain patient safety.
Research design: A descriptive correlational research design was utilized. Study setting: the study
was conducted at cardiovascular hospital affiliated to Ain Shams University Hospitals. Study
subjects: included all available staff nurses, total number is 120 staff nurses. Data collection
tool: Self-administered questionnaire sheet to assess challenges facing staff nurses to maintain
patient safety. Results: There were more than 50% of the studied staff nurses had high level of
challenges regarding to work environment, task &technology, institutional context, teamwork and
organization & management related challenges. Also, 50% of them had high level of challenges
regarding to individual staff related challenges, and 48.3% of them had high level of challenges
regarding to patient related challenges. Conclusion: it is concluded that 55% of the studied staff
nurses had high level of total challenges facing them to maintain patient safety. Also, there were
highly statistically positive correlation between patient related challenges and teamwork, task &
technology and institutional context related challenges. Recommendation: Conduct training
programs for staff nurses to improve knowledge and practices related to patient safety, conduct
educational programs for patients about their safety and rights and responsibilities, developing
unique handover system for staff nurses and training them for applying it and providing training
program for nurses about analyzing and documentation of risks.