Background: Talent management is increasingly discussed in the human resource management and human resource development literature. It is a set of practices that are implemented in organizations and refers to how organizations attract, select, develop and manage employees in an integrated and strategic way. The study aim: To investigate the effect of talent management training program on head nurses leadership effectiveness. Research design: A quasi-experimental research design was utilized. Setting: The study was conducted at all inpatient units (medical surgical) and critical care units (N=15) Damanhour National Medical Institute (head nurses =120). Tools: Tool I: To assess head nurses' knowledge regarding talent management (pre/posttest). Tool II: Talent management questionnaire; to assess talent management practices among head nurses. Tool III: Leadership effectiveness questionnaire: to assess leadership effectiveness among head nurses. Results:  there is a highly statistically significant improvement in head nurse's knowledge and practice regarding talent management in the post phase and follow-up phase compared to their pre-intervention. Conclusion: the application of the training program had a positive impact on enhancing head nurses' knowledge and practice regarding talent management and also total leadership effectiveness level was improved markedly throughout program phases. Recommendations: Conduct a talent management workshop periodically for all head nurses as a refreshment course. Providing talent management programs and workshops for newly hired head nurse in the organization.