Background: Mobile-based nursing intervention is a trial to enable children to be safe during the
COVID-19 epidemic especially those children with chronic kidney disease and who have no
immunity. Now days using mobile becomes a part of universal technology for improving the care of
children with such conditions. This study aimed to evaluate the effect of mobile-based nursing
intervention on preventive measures of COVID-19 among children suffering from chronic kidney
diseases. Design: A quasi-experimental design was adopted. Sample: A purposive sample including
70 children suffering from chronic kidney diseases with predetermined criteria (receive regular
kidney dialysis, have no history of previous COVID-19 or previous kidney disease complications
and well-being mental health) setting: The study was conducted at the Pediatric Kidney Dialysis
Unit at Sohag University Hospital. Tools for data collection: A structured questionnaire was used
to collect data concerning characteristics of the studied children (pre/posttest questionnaire) as well
as to assess the level of child knowledge regarding mobile intervention, preventive measures of
COVID-19 and dialysis therapy, a checklist to assess reported practice as regards preventive
measure of COVID-19. And Mobile-based nursing intervention which had been designed by the
researchers. Results: There was a statistically significant difference towards using mobile-based
nursing intervention in the area of children's knowledge and practice about COVID-19 preventive
measures at post-intervention compared to pre-intervention. Conclusion: Mobile-based nursing
intervention had a positive effect on improving preventive measures of COVID-19 among children
suffering from chronic kidney diseases. Recommendations: apply mobile-based intervention in
other pediatric kidney dialysis units and hospitals to achieve a better preventive measure of COVID-
19 among children with chronic disease.