Thalassemia is the most common hereditary hemoglobinopathy, enhancing self-efficacy in
children's with thalassemia remains so important; as it is related to the capability to achieve some
important goals together with their psychological well-being . Aim: The study aimed to evaluate the
effect of empowerment program on self-efficacy among children with thalassemia. Methods: One-
group quasi- experimental design with pre-post evaluation, which was conducted in the hematology
clinics at El-Monira pediatric hospital, affiliated to Cairo- University. A purposive sample of 100
children, aged from 8-12 years old. Tools: 1) Structured interview sheet, 2) knowledge structured
questionnaire, 3) and the self-efficacy questionnaire for children were used for data collection.
Results: All children had unsatisfactory knowledge about thalassemia before the program
implementation. Meanwhile, for total knowledge satisfactory level of children increased to slightly,
more than three quarter, near to three fifths, immediate post and one month after the program
respectively with highly statistically significant difference P <. 0.001. Also, highly significant
improvements of academic, social and emotional self-efficacy of children were observed after one
month P <. 0.001. Conclusion: Significant improvement in knowledge of children detected
immediate post and one month after the empowerment program, but self–efficacy improved
significantly only after one month. Recommendations: The study recommended that the
empowerment program should be implemented in the routine care for children with thalassemia.