Background: Infertile men could suffer from episodes of depression, anxiety; anger, isolation, sense of personal failure and affect the quality of marital relationships between the couples. The study aimed to assess depression, anxiety and marital satisfaction among infertile males and determine relationship between depression, anxiety and marital satisfaction among them.  Subjects & method: A non-experimental (case-control) research design was used. A purposive sample was used. The current study included 100 subjects (50 were studied group & 50 were control group). The study was conducted at outpatient clinic of andrology and sexual transmitted diseases in Assiut University Hospital, Egypt. Tools of study consisted of four tools: Demographic and clinical data assessment questionnaire, Beck depression inventory (BDI), Beck Anxiety Inventory (BAI), and Marital Satisfaction Scale. Results: The most of infertile and fertile age groups was ranged from 28 to <38 years old. 64% of infertile males and 60% of fertile males were from rural area. 56% of infertile males reported that their duration of infertility ranged from 1-3 years. Infertile males have higher level of depression and anxiety ((34% and 32% respectively) than fertile males and there are statistically significant differences between infertile and fertile males regarding total of marital satisfaction. Conclusion Infertile males have moderate to severe levels of depression, anxiety and marital un-satisfaction than fertile males. Recommendations: Psycho-education program can be designed and implemented for the infertile males to improve depression, anxiety and marital satisfaction among them.