Background: The outbreak of coronavirus disease (COVID-19) has put significant pressure on both employers and employees, and emotional intelligence (EI) is essential for effectively managing stress effectively during this period. Aim: This research intended to assess the relation between emotional intelligence and coping patterns with stress among nurses during the COVID-19 pandemic. Design: A correlational, descriptive design was used for related studies. Setting: The research was at Ain Shams University Hospital, which is allied to Ain Shams University Hospitals. Subjects: A convenience sample included 241 nurses among the 550 who were eligible to participate in this study. Data collection: The Emotional Intelligence Scale and the Brief Cope Scale were utilized in this study. Results: A total of 72.2% of the participants had the lowest total level of emotional intelligence and an elevated mean (27.1 ± 17.04, 26.1 ± 2.04, 15. 3 ± 12.04, 15. 3 ± 12.04 and 15.0 ± 2.05 and 6.1 ± 2.03) were used for self-awareness, social skills, empathy, managing emotions, optimism, and utilization of other emotion subscales, respectively. The highest mean score (41.75 ± 10.674) was for maladaptive coping. Conclusion: There was a statistically significant positive correlation between total emotional intelligence and coping patterns among the studied nurses. Recommendations: Administrators should be informed of the coping procedure and EI of nurses' contributions to defining ways to prevent emotional exhaustion and improve their job performance while they face work challenges. The development of training programs aimed at enhancing both professional and personal results ensures that nurses are well equipped with emotional intelligence and coping strategies during critical times, such as the pandemic and its aftermath.