The coronavirus disease (COVID-19) epidemic resulted in both physical and mental health
problems. Aim: To determine the emergency nurses' professional quality of life and mental health
outcomes during the COVID-19 epidemic. Method: The present study utilized a descriptive cross
sectional research design. The subjects consisted of 171 emergency nurses who were selected
according to inclusion and exclusion criteria. The study was carried out in Egypt's emergency
departments affiliated with Mansoura University Hospitals (Mansoura Emergency Hospital,
Gastrointestinal Surgery Center, and Oncology Center). Tools of data collection included the
demographic interview sheet, the professional quality of life scale version 5, the general anxiety
disorder 7, and the patient health questionnaire. Results: There is a significant relationship between
professional quality of life, anxiety, and depression among the studied nurses. Conclusion: There is
a moderate level of compassion fatigue, burnout, anxiety, and depression among nurses.