Endometriosis is one of the most common benign gynecological disorders that affects
approximately 5-15% of women within their reproductive age. Endometriosis-related pain and
fatigue are common and adversely impact several areas of many women's lives. Aim: The study
aimed to investigate the effect of nursing program regarding lifestyle modification on selected
outcomes among women with endometriosis Design: A quasi-experimental study design control,
and study group was used. Setting: The study was conducted at the outpatient gynecological
department at Beni-Suef University Hospital. Data collected for 9 months from the beginning first
September 2019 to the end of May 2020. Sample: A purposive sample approach of 60 women was
included in the study. Tools: Five tools were used for data collection, Sociodemographic
characteristics, Self-care practice, Endometriosis health profile questionnaire, Hamilton Rating
Scale for depression, and Hamilton Anxiety Rating Scale. A procedure was carried out through four
phases as initial assessment, planning, implementation, and evaluation phase. Results: There were
statistically significant differences between pre- and post-program implementation in study group
regarding all selected outcomes: knowledge (f:0.169, p:0.001), practice (f:3.058, p:0.017), fatigue
(f:4.887, p:0.001), pain (f:5.58, p:0.002), and depression (f:2.257, p:0.040). moreover, there were
significant statistical differences for all items in the study group regarding lifestyle modification.
Conclusion: The implementation of nursing programs regarding lifestyle modifications such as
(healthy dietary habits, physical activity, and stress management) for women with endometriosis has
shown improvement in their knowledge and reduce endometriosis-related symptoms (depression,
anxiety, fatigue, and pain). Recommendation: Nursing programs regarding lifestyle modifications
should be applied for all women with endometriosis, and online easily accessible nursing programs
regarding lifestyle are also needed, with further research on their utilization and usefulness