Background: Preeclampsia during pregnancy is considered one of the major obstetrical
problems in developing countries that cause maternal mortality and preterm birth throughout the
world. Aim: To evaluate the effect of nursing intervention guided by PRECEDE model on
knowledge and practice of preventive behavior of high-risk pregnant women regarding
preeclampsia. Subjects and method: Design: Quasi-experimental research design pre-post-test
was utilized in this research. Settings: The study was applied in the antenatal outpatient clinics at
Tanta and Sohag University Hospitals. Sample: A purposive sample of 120 high-risk pregnant
women was recruited from the selected settings. Tools: Four tools were used: (1) Structured
interviewing questionnaire, (2) Predisposing, Enabling, and Reinforcing Questionnaire
(PRECEDE model questionnaire), (3) Pregnant women's reported practices of preeclampsia
preventive behavior tool and (4) Pregnant women attitude questionnaire regarding preeclampsia
prevention. Results: Mean score of knowledge, enabling factors and reinforcing factors have been
increased with statistical significance immediately and after one month of nursing intervention
implementation. Pregnant women had good practices toward preeclampsia preventive measures
one-month post-intervention in comparison to the pre-intervention implementation. Pregnant
women had a positive attitude toward preeclampsia preventive measures one-month post-
intervention in comparison to the pre-intervention implementation. There was a statistically
significant relationship between knowledge, enabling, reinforcing factors score and practices
scores of preeclampsia preventive measures throughout the intervention phases. Conclusion: It
was concluded that implementing nursing intervention guided by PRECEDE model in high-risk
pregnant women was effective in improving knowledge and practice regarding the prevention of
preeclampsia. Recommendation: The nursing intervention guided by PRECEDE model
regarding preeclampsia prevention should be integrated into the antenatal care for pregnant
women in the study setting. Replication of the current study on a larger probability sample is
recommended to achieve generalizability.