Background: Compassion fatigue among nurses has a negative influence on them and the quality of care they provide. The aim of this study was to evaluate the effect of an educational program on compassion fatigue and compassion satisfaction among psychiatric nurses. Subjects and Methods: Research design: A Quazi experimental design (single group pre-post-test) was utilized in this study. Subjects: A purposeful sample of 105 psychiatric nurses was included in this study. Setting: This study was carried out at El-Azazi Mental Health Hospital in Abo Hamad City, Elsharkia Governorate, Egypt. Tools of data collection: Nurse's Interviewing Questionnaire sheet and Professional Quality of Life Scale were used to collect data for this study. Results: The percent of nurses experiencing high level of compassion satisfaction have been increased from (58.1%) at pre-program to (85.7%) at post program period. While, burnout score has been decreased from 70.5% at pre-program to 34.3% at post program period among studied nurses. As well as secondary traumatic stress score have been decreased from 73.3% at pre-program to 61.9% at post program period among studied nurses. Conclusion: The educational program was effective in reducing the level of burnout and secondary traumatic stress (compassion fatigue) and enhancing the level of compassion satisfaction among studied psychiatric nurses. Recommendations: Providing psychosocial counseling for psychiatric nurses experiencing compassion fatigue (CF) can increase their abilities to understand the ways compassion fatigue affects various dimensions of their lives, so they can be better equipped to develop and refine internal coping skills which help them in managing the difficult nature of their job.