Background: Workers in quarries who engage in the excavation, cutting, and crushing of stones or rocks are exposed to various hazards, including noise, falls, dust, and explosions. Aim: The study aimed to propose guidelines for preventive measures toward occupational health hazards for quarries workers. Study design: A descriptive analytical study was utilized to conduct this study. Subject: A purposeful sample consisted of 302 male workers in limestone quarries. Setting: This study was conducted in the quarries of Tourah affiliated to Tourah Portland Cement Company in south of Cairo. Tools: Composed of 3 tools.: I tool: An interviewing questionnaire form. II tool: Observational Check list about compliance of personal protective equipment. III tool: Medical record. Results:59.9% of workers their aged ranged from 25˂ 40 years old, 51.0% work 7 to 8 hours a day, the most common occupational health hazards were dust pollution, noise pollution, and weather hotness, while 83.1% of them complained of wounds, and 70.5% body pain, also 72.8% of them diagnosed with musculoskeletal diseases. 49% chronic bronchitis and 44.4% silicosis while the workers who compliance with personal protective equipment represent only 18.2% of total workers. Conclusion: The study demonstrated the existence of a statistically significant relationship between exposure to occupational hazards and compliance with personal protective equipment and statistically significant relationship between workers' knowledge and practices towards prevention of occupational hazards and the incidence of work injuries among them with p value ˂ 0.001. Recommendation: Activating the proposal guideline for preventive measures toward occupational health hazards to raise awareness of quarry workers.