Nurses' attitude, psychological response, and compliance with infection control practices are the key to
quality care and excellence in Covid-19 patient care; infection control remains one of the most cost
beneficial and requires full compliance of the whole nursing team. The aim of the study was to
compare and examine the nurse's attitude, psychological response, and practices compliance with
infection control measures during Covid- 19 outbreak. Design: Descriptive comparative research
design. Sample and Setting: A convenient sample was used in the current study, which included all
staff nurses (241 nurses) who working in isolation hospitals (Minia cardio-thoracic university hospital
(114 nurses) and Minia fever hospital (127 nurses). Tools: Data was collected through the utilization
of three tools as follow: Tool (1) Nursing attitude about Covid-19 outbreak consisted of two parts; Part
I: Demographic data, Part (II): A self-administered structured attitude questionnaire; Tool (2): A self
administered structured psychological response questionnaire, and final Tool (3): An observation
practice checklist. Results: The current study revealed that 71.7% of the studied nurses working in the
Minia fever hospital compared to 86.0% of the studied nurses working in the Minia cardio-thoracic
university hospital had a favorable attitude toward coronavirus patients, 26.8 % compared to 100.0%
of them had undisturbed psychological responses respectively and 73.2% compared to 98.2% of them
had compliance regarding infection prevention practice respectively with highly statistically
significant differences which P-value < 0.007, 0.0001, and 0.0001 respectively. Conclusion: Nurses in
both of the two isolation hospitals had a favorable attitude toward coronavirus patients, with
undisturbed psychological responses, and they had compliance regarding infection prevention practice.
Recommendations: Continuous education and training for all health sectors for increasing nurses'
knowledge and awareness about all waves of the Covid -19 virus.