Background: Chronic renal failure (CRF) is a worldwide public health problem with an increasing incidence and prevalence. Assessment of biopsychosocial needs of patients with CRF is an important nursing role helping to provide a comprehensive patient's care. Aim of study: The study aimed to assess biopsychosocial needs for patients with chronic renal failure. Study design: A descriptive exploratory design was used. Settings: The study was conducted at Hemodialysis Units, which is affiliated to Ain Shams University Hospitals. Subjects: A purposive sample of 137 patients with chronic renal failure attending the previous mentioned settings. Tools of data collection: I- Patient's interviewing questionnaire. II- Patient's biopsychosocial needs questionnaires:- was assessed through using;-1-Barthel Index 2-Anxiety assessment scale 3-Beck depression inventory 4- Social Dysfunction Rating Scale. Results: 78.1% of studied patients had unsatisfactory level of total knowledge. 76.5% of studied patients were independent, 48.9% of studied patient had mild anxiety, and 71.5% of them had mild depression and 51.1% of them had mild social dysfunction. Conclusion: a majority of patients had unsatisfactory knowledge regarding disease, the highest needs for patient with CRF were the psychological needs followed by social and physical needs. Recommendations: A simplified, illustrated and comprehensive Arabic booklet including information about disease should be available for patients and supportive care services in dialysis setting should be directed towards meeting biopsychosocial needs of patients with CRF.