Background: Menstrual symptoms play a major role in the socio- academic performance of some adolescent female students; menstruation related symptoms may have negative influences on their academic performance and social activities. Aim: assess the correlation between menstrual problems and socio- academic performance among nursing students at Ain Shams University. Subject and Methods: This study was descriptive correlation, A purposive sample was selected and performed on 400 students at faculty of Nursing Ain Shams University. Tools of data collection: Data was collected using 1) structured interviewing Questionnaire, 2) menstrual characteristics tools and 3) Pediatric quality of life Generic Core Scales. Results: The study shows that the majority of the studied sample had premenstrual syndrome and dysmenorrhea, one third had hypomenorrhea and twenty had oligomenorrhea three quarters had regular cycles, less than half had low level of social health and more than half had low level of academic performance, there were statistically significant correlations between menstrual cycle regularity, amount of blood loss, dysmenorrheal, premenstrual syndrome and their total academic performance. Conclusion: The current study concluded a significant correlation between menstrual problems and students' socio-academic performance. Recommendation: Conducting reproductive health programs for female undergraduates including information about menstrual hygiene, menstrual disorders, and their management.