Background: In intensive care unit (ICU), sepsis is a main cause of death for the survival of
patient with this condition, early identification and management is necessary. Aim of this study was
to investigate the effect of evidence based sepsis care bundle on patient outcome in medical
intensive care unit. Method: Quasi-experimental research strategy was used in this study the sample
was included 100 adult critically ill patients taken from medical intensive care in Aswan University
Hospital. Tool (I): Patient assessment sheet was used for collecting data, which included two parts:
bio-demographic data and medical data, Tool (II): evidence based sepsis care bundle, to control
mortality frequency and diminished length of stay within medical ICU. Results: ICU stay, the half
of the usual care group stayed one week and majority (46%) of the bundle care group stayed less
than one week. As regarding mortality rate was lowered than the control group with a substantial
variation (P = 0.021). Conclusion: implementation of the evidence-based sepsis care bundle to all
critically ill sepsis patients can promote optimal patient outcome. Recommendation: must
be
reduplication this study in a large probability sample in the different critical care setting area.