Background: The aging period associated with multiple losses affects self-compassion in older adults and consequently reduces life satisfaction and psychological well-being. Self-compassion-based interventions can improve older adults' lives through the promotion of well-being and life satisfaction. Aim: This study aimed to evaluate the effect of a self-compassion-based intervention on life satisfaction and psychological well-being among older adults. Subject and Methods: Quasi-experimental research design, pre-posttest was used for one group of older adults. Setting: The study was conducted in a geriatric home in Tanta City. Subject: A convenient sample of all available older adults with a total number of 70 was recruited from the selected geriatric home. Tools of data collection: I: Interviewing questionnaire, II: Self-Compassion Scale, III: Satisfaction with Life Scale, and IV: Psychological Well-Being scale Results: The mean age of the elderly participants is 73.7±7.4 years old,   52.9% of the elderly participants was females. There was a highly statistically significant improvement in total scores of psychological well-being pre and post-test. A highly statistically significant increase in the total score of pre and post-test life satisfaction was found among the elderly participants. Self-compassion total score and subscale score among the study group pre/posttest show a highly statistically significant difference (P<0.000). Conclusion: The current study highlights the importance of self-compassion-based intervention to promote life satisfaction and psychological wellbeing of older adults in a geriatric home. The study recommendations: The conduction of self-compassion-based intervention for older adults in different settings to gain optimal life satisfaction and psychological wellbeing. Moreover; it supports successful aging and active life concept for seniors.