Background: Obsessive Compulsive Disorder (OCD) is one of most frequently diagnosed psychiatric illness, tends to run a chronic course. Patients with Obsessive-Compulsive disorder suffer from obsessive thinking and compulsive behavior, which has a great impact on their everyday life.  Aim: this study aimed to assess the relationship between quality of life and self- efficacy among patients with obsessive compulsive disorder.  Research Design: A descriptive correlational study design was used to conduct the study. Setting: This study was conducted at Out-Patient Clinic in El Abassia Mental Health Hospital affiliated to Egyptian Ministry of health. Sample:
A purposive sample was obtained included 50 patients with obsessive compulsive disorder. Tools of data collection: The data was collected using an interview questionnaire sheets that included three parts as following: 1) A structured interview schedule to assess demographic Characteristics of patients with obsessive compulsive disorder. 2). World Health Organization Questionnaire on Quality of Life 3) General Self-Efficacy Scale. Results: The current study revealed that: there were highly percentages of patients with obsessive compulsive disorder under study have poor quality of life and have low self –efficacy ; also, there was a moderate positive correlation between quality of life and self-efficacy among patients with obsessive compulsive disorder. Conclusion: According to the results of this study, it can be concluded that This is a moderate positive correlation between quality of life and self-efficacy among patients with obsessive compulsive disorder. Recommendations: Psycho educational intervention program should be designed to reduce the negative implications of OCD and to improve QOL among patients with obsessive compulsive disorder and designing a psychosocial nursing intervention program to patients with OCD for enhancing their self- efficacy.