Background: Antiphospholipid syndrome (APS) is a complex autoimmune disorder that increase risk
thromboembolic events that result in various problem for pregnant woman as sever preeclampsia, miscarriage ,
still birth , preterm labor. This study aimed to assess maternity staff nurses knowledge regarding
antiphospholipid syndrome. A descriptive study design was used. This study conducted at high risk pregnancy
unit at Ain Shams Maternity Hospital. A convenient sample was used to recruit two hundred twenty five staff
nurses working in Ain Shams maternity university hospital. Data were collected through structured interview
questionnaire. The result of the study shows that 79.6% of the studied nurses had unsatisfactory knowledge
regarding APS. Conclusion and recommendations: The study concluded that most of the studied maternity
staff nurses had unsatisfactory level of knowledge regarding antiphospholipid syndrome. Accordingly, the
following recommendation is proposed: Developing a training program, booklets, and guidelines for
maternity staff nurses for improving their level of knowledge regarding antiphospholipid syndrome.