Background: Women's safety and quality of care are essential aspects of clinical nursing
practice. Medication administration errors are considered to be a global problem resulting in an
increase in mortality rates, length of hospital stay, and related costs. Aim of the study to assess
the effect of maternity nurse's knowledge, and Practices regarding the medication errors on
laboring women safety in labor unit. Design: A descriptive research design was used in this
study in labor unit. Setting: The study was conducted at the maternity departments of University
hospital, General hospital (Alnubui Almuhandis) and Tamia hospital at Fayoum city. Sample:
Convenience sample technique was utilized in the present study to recruit 40 nurses. Tools: Three
tools for data collection. First tool: Self-administered questionnaire sheet which used to assess:
personal data of the studied sample nurse's knowledge related to specified obstetric medication
and precautions of medications administration. Second tool: Factors that influence medication
errors from the nurse's point of view. Third tool: An Observational Checklist: to assess the
maternity nurse's practices related to obstetric medication administration and errors. Result: the
present study showed that the total score of maternity nurse's knowledge regarding medication
administration in labor unit was, slightly more than half of the studied sample had incomplete
satisfactory knowledge. On the other hand the total score of maternity nurse's practices related to
medication administration was, slightly less than half of the studied sample had complete
satisfactory level of practices regarding medication administration, moreover, there was significant
relationship between level knowledge and practices. Conclusion: Slightly more than half of the
studied nurse's had incomplete satisfactory knowledge regarding medication administration in
labor unit. While, slightly less than half of the studied nurse's had an complete satisfactory level
of practice regarding medication administration in labor unit. Recommendation: in service
training programs is required for maternity nurses regarding medication errors and how to overcome
it.