Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic and potentially life-threatening
complication of fertility treatment. Aim: To evaluate the effect of supportive guidelines on nurses'
knowledge and practices regarding ovarian hyperstimulation syndrome. Study design: quasi
experimental pre and posttest research design was applied. Setting: The current research was
carried out at all infertility treatment centers in Minia city (El Nile, Jannah, Minia center, and Egypt
center). Sample: A convenient sample was utilized in the current study, 60 nurses who agree to
participate. Tools: data were gathered via three tools: the first include socio-demographic data,
knowledge assessment tool, and practices observational checklist regarding OHSS prevention.
Results: it reveals that 76.7 % of the participants had poor knowledge about OHSS in pretest
reduced to 6.7% in posttest. And 71.7 % of the participants had unsatisfactory practices regarding
OHSS prevention in pretest which decreased to 21.7% in posttest. Furthermore there was a positive
correlation between studied sample's knowledge and practices in pretest and posttest with
statistically significant differences where p_ value was .001. Conclusion: There were highly
statistically significant improvements in nurses' knowledge and practices regarding OHSS after
implementation of supportive guidelines. Recommendation: Provide a continuous planned
educational courses for nurses in infertility treatment centers and clinics to update their knowledge
continuously and improving their practices regarding preventing OHSS and, routinely provide a
brochure or a booklet that contain all information about OHSS for every women receiving ovulation
induction medication in all infertility centers or clinics.