term physiological and emotional wellbeing. A qausi- experimental study design aimed to evaluate the effect of self-care guideline versus counseling on post cesarean section women practices. The study was conducted at antenatal clinic, postpartum cesarean section and family planning clinics at Ain Shams University Maternity Hospital. 370 women had cesarean section delivery were included in the study for purposive sample technique, those were equally divided into guideline and counseling group. Three tools of data collection were used named interviewing questionnaire to contain socio-demographic data, obstetric history, pre- test and post-test for assessing effect of self-care guideline versus counseling on post cesarean section women practices. groups and women follow up card. The main result of the current study revealed that, There was no statistically significant difference between both groups regarding total knowledge level regarding self-care after CS and before the intervention. There was no statistically significant difference between both groups regarding total practical level of studied women about self care after CS before the intervention. There was statistically significant difference between two groups regarding total knowledge level after CS in the 6th week of delivery after intervention. There was statistically significant difference between two groups regarding total practical level of studied women after CS (at the end of the 1st, 3rd, 6th week after CS after CS). There was highly statistically significant difference between pre and at the 6th week after CS regarding women knowledge in both groups. The present study concluded that self-care guideline has a positive effect to enhance self-care knowledge & practices among post cesarean section woman than counseling. The researcher recommended conduction of awareness sessions for mothers antenatal units regarding self care guideline for women during antenatal period to enhance self care knowledge and practice among pregnant woman.