Background: Lymphoma is the most common cancer in childhood body. Aim: evaluate educational program for mothers regarding children suffering lymphoma disease. Design: a quasi-experimental study was used. Setting: Oncology unit (day care unit) in Nasser Institute Hospital. The sample: A purposive sample of 53 mothers having children with lymphoma. Tools: two tools were used for collected data first tool: An interview questionnaire used to collect data from mothers related to demographic characteristics for mothers and their children, past medical history for mothers and present medical history for children, health problems for children with lymphoma, health needs for children mother's knowledge related to lymphoma and mothers practices for caring their children with lymphoma. Second tool: medical record for children. Results: the present study revealed that, the age of mothers approximately two fifth of mothers their age ranged from 30-40 years. There is statistically significant relation pre and post program related to mother's knowledge. There is statistically significant relation pre and post program related to mother's a practice there is significant correlation mothers satisfaction practices pre and post program about lymphoma. There is significant correlation between age, education levels and occupational with mother's practices about lymphoma. Conclusion: based on the finding of the present study, it can be concluded that there was improvement knowledge and practices regarding their children with lymphoma disease .Recommendations: Ongoing health education is highly needed for the mothers regarding their children with lymphoma disease, Replication of the study on a larger sample and on different geographical settings to allow generalization of findings.