Background: Implanted port is an implanted device giving access to veins for patients with difficult veins or who need regular long-term administration of drugs often need to be delivered into a large central vein. Aim: The aim of this study was conducted to assess nurses' performance (knowledge, practice& attitude) for caring of patients with implanted port undergoing chemotherapy. Research design: An exploratory descriptive design was utilized to achieve the aim of the study. Setting: The study was conducted at the oncology department in the El-Demerdash Hospital affiliated to Ain Shams University. Study subject: A convenience sample of (50) nurses working in the previously mentioned unit within 6 months. Tools: three tools were used including: - I- Self-administered questionnaire: it used to assess nurses' knowledge, factors affecting on their performance and demographic characteristics of the study nurses. II-Nurses' performance observational checklist: it used to assess nurses' practice in caring of patients with implanted port. III-Likert scale: it used to assess nurses' attitude in caring of patients with implanted port. Results & Conclusion: more than three quarter of nurses had inadequate practice, and more than two third of them had inadequate knowledge while more than half of them had a positive attitude regarding caring of patients with implanted port. Recommendations: Further research are recommended periodically to study new approaches in the area of management of patients with implanted port and evaluate its reflection on patient's outcomes.