Background: Acne vulgaris is chronic inflammatory skin disease impacts on patient's physical and mental health. The aim of this study was to examine the psychological problems of adolescent related to acne vulgaris (depressive symptoms, body image and self-esteem). Descriptive correlational design was utilized to achieve the aim of this study. This study was conducted at the outpatient clinic of the Dermatological Hospital in Benha City. A convenience sample of 200 patients fulfilled the inclusion and exclusion criteria during the spring season were selected from the above setting. The study tools were composed of four Tools (1): Socio-Demographic and Clinical Data, Tool (2): Beck Depression Inventory Scale to measure depressive symptoms, Tools (3) Rosenberg Scale to assess self-esteem, Tool (4) Body Image Scale to measure body image. The results of the study revealed that there was a statistical significant relationship between acne vulgaris and depressive symptoms, body image and self-esteem. Based on the results of this study it was concluded that: Acne vulgaris influence negatively on patients' psychological status. The study recommended that: Psychological counseling should be integrated as nursing intervention for acne patients to improve their mood, self-esteem and body image.