Background: Motivation is a concept used to describe an external state inspiring a special behavior and internal responses revealing that behavior. Empowerment means engaging employees in the thinking processes of an organization, getting employee's ownership of their jobs and the resulting products or services produced by it. Aim of the study: The study aimed to exploring the relationship between motivating work factors and empowerment among staff nurses Setting & subjects: Research design: a descriptive correlational design utilized in carrying out .The study conducted on 140 staff nurses working at Met Ghamer Hospital; which affiliated to Ministry of Health, Tools of data collection: two tools used namely motivating work factors questionnaire and the condition for work effectiveness questionnaire. Results: majority (95%) of the studied subjects had low perception regarding total motivating work factors. In addition, majority (96.4%) of the studied subjects had low empowerment levels Conclusion: there were highly statistically significant positive correlations between motivating work factors and sources of empowerment among staff nurses. Recommendations: Support nurses' professional development and self-determination.