Background: Advocacy is the essence of nursing's professional commitment to the preservation of human rights, protection of patients from harm, and the provision of quality patient care. Aim: To investigate the nurses' advocacy toward patients and its relation toward patients' satisfaction. Design: Descriptive correlational design was used in this study. Sample: The study subjects included (33) nurses and (120) patients both male and female. Setting: Data was collected from inpatient units at Badr University Hospital affiliated to Helwan University in Egypt. Tools: Two tools were used for data collection: Protective Nursing Advocacy Scale and Patients' satisfaction toward advocacy questionnaire. Results: The majority of studied nurses had high advocacy toward their patients (91.9%), and the majority of studied patients were highly satisfied with nursing advocacy (98.2%). Conclusion: The study concluded that, there was a moderate significant positive correlation between total protective nursing advocacy scale and total patients' satisfaction toward nursing advocacy, which answer the research question Recommendations: Incorporate nursing advocacy concepts and patient rights into the nursing curriculum in order to cultivate growth of the nursing student's advocacy abilities needed to work with patients in different clinical settings.