Renal transplantation is the surgical implantation of a human functioning kidney from either living donor or a cadaver into a patient with end-stage renal failure. Aim of the study: to assess biopsychosocial needs of patients post renal transplant. Design: A descriptive exploratory design was utilized. Setting: this study was conducted at out-patient clinics of the National Institute of Nephrology and Urology in Matariya Hospital. Study subjects: A Purposive sample including all patients admitted to outpatient clinics in the previous mentioned setting. Data collection tools: 1)Patient`s interviewing questionnaire, it includes the following parts, 1) concerned with demographic characteristics of the study subjects (age, gender and marital status),2) Past medical history of patients under study,) Biopsychosocial needs assessment sheet including the following sections: A) Physical needs assessment, B) Psychological needs assessment, C)Social needs assessment, D) Educational needs assessment. Results: the study showed that, the common systemic needs among studied patients were cardiovascular system alterations followed by rest and sleep alterations. Regarding daily living activity function, it was found that more than one third of patients under study had severe function impairment. Conclusion: this study concluded that, regarding psychological needs, it was found more than one third of study subjects had moderate depression and extremely severe anxiety level. Recommendation: the study recommended supportive care services in any hospital care setting should be directed towards meeting biopsychosocial needs of patients post renal transplant.