Parents dealing with childhood cancer face many different stressors throughout the course of their child's illness. The responsibility is often on caregivers. Aim of the study was to assess the effect of discharge plan for children undergoing chemotherapy and their caregivers on improving practice and coping pattern. Research design: Quasi - experimental design was utilized. Settings: The study was conducted at Children Hospital affiliated to Ain Shams University and Pediatric oncology unit in National Cancer Institute affiliated to Cairo University (NCICU). Subjects: Purposive sample of 50 caregivers of children undergoing chemotherapy were recruited from the previously mentioned settings. Tools: A data were collected by using; interview questionnaire format(before and after implementation of discharge plan) to assess informational needs, Observational checklists to assess practical needs, anxiety & depression scale and coping scale to assess emotional and psychological needs. Results: This study revealed that more than half of caregivers were primary school. Less than two thirds of caregivers‟ knowledge gained good scores after intervention. There is a statistically significant difference between caregivers' knowledge before and after implementation. Only one quarter of caregivers had no anxiety before intervention compared to less than half of them after intervention. Conclusion: This study concluded that caregivers who received discharge plan showed improving in knowledge and practice regarding care of their children, experiencing less level of anxiety and coping with stressful events during children illness. Recommendation: the study recommended that multidisciplinary team should be involved in teaching and helping the caregivers and their children to be managed from an apparently common sequence of physical and emotional reactions.