This study was aimed to assess pregnant women knowledge regarding the oral health care. Study setting: The study was conducted at ante natal outpatient clinic At Ain Shams University Maternity Hospital. Study design: A descriptive study design was used. subjects and method : The study was conducted among pregnant women were attended at antenatal outpatient clinic At Ain Shams University Hospital 265. Study simple: Purposive sample. Study Tools: Self – administered structured questionnaire sheet, was developed to collect data. Result: There were three quarters of study sample of pregnant women had unsatisfactory knowledge about oral health care during pregnancy. Conclusion: the current study concluded that most of the study sample had unsatisfactory knowledge regard oral health care during their pregnancy period. Recommendations: Emphasize the importance of oral health care during pregnancy to prevent the oral health problems for both mothers and their infants.