This study aimed: to assess the pediatric nurses' knowledge and skills regarding care of children undergoing open heart surgery. Design: A descriptive deign was utilized in conducting the study. Setting`: This study was conducted at Abou El-Resh Talabah Hospital Affiliated to health insurance and Cardiac Surgery Academy affiliated to Ain Shams University Hospitals. Subject: A purposive sample of nurses who give care to children undergoing open heart surgery, they were all (80) nurses . Tools of data collection: questionnaire sheet and observational checklists. Results: This study revealed that more than half of the studied nurses in the age between 20-30 years and married also, not attended any training programs, more than half of them (61.3%) had unsatisfactory knowledge, while the majority of them (77.5%) had competent performance regarding caring of children undergoing open heart surgery. Conclusion: this study concluded that more than half of the studied nurses had unsatisfied knowledge although the majority of them have competent practices during providing nursing care for children undergoing open heart surgery. Recommendation: Educational program should be carried out in order to currence quality of care that was provided to children undergoing open heart surgery .