Major depressive disorder is the second leading disease causing functional impairment and
disability. It is a prevalent health problem which is associated with diminished life quality, and
significant physical and psychosocial impairment. Therefore, the current study aimed to enhance
quality of life and decrease depressive symptoms for patients with depression through utilization
of supportive psychotherapy. This study was conducted on 40 patients during their follow-up
visits to the Outpatient Clinic, Al-Abbassia Mental Health Hospital. Data were collected using: 1)
Interviewing questionnaire sheet including, socio-demographic data, history of depression and the
patient's knowledge regarding depression. 2) Beck's Depression Inventory. 3) World Health
Organization Quality of life Scale. The main result of this study showed that, there is a highly
statistically significant difference between pre-post program implementation as regards patients
knowledge about depression, level of depression and their total score of quality life domains. The
study concluded that, utilization of supportive psychotherapy showed great enhancement of
quality of life and decrease in depressive symptoms among patients with depression. The study
recommended that the concept of supportive psychotherapy and quality of life should be
integrated in nursing education curriculum to help nursing staff to guide patients with depression
and their families on how to avoid and/or cope with depression to maintain normal life style at
highest possible level of quality of life.