Background: Hysterectomy, which is the surgical removal of the uterus and cervix, is the commonest major gynecological operation in both developed and developing countries. The aim of the study was to estimate the types, indications, complications of hysterectomy and evaluate the effectiveness of nursing interventions program on patients undergoing hysterectomy operation. A prospective descriptive Research design was used to investigate the current research problem over a one-year period between June 2015 to the end of May 2016 and patients number was235 &quasi-experimental for the implemented nursing intervention program (20) nurse. The research was conducted in the department of gynecology, at Zagazig University hospital. Results the prevalence of hysterectomy was 33.5% according to 2016 hospital record. The mean age and parity were 48.7 ±9.6 years and 4.3 ± 2.3respectively, 77.9 % of the studied patients underwent AH, the rest had vaginal and laparoscopic approach (11.5% &10.6% respectively). The most common indications were leiomyomata (62.6%) & bleeding disorders (60.0%) and complications were present in 27.7%, A statistically significant improvements were observed at the posttest in all areas of tested nurses' knowledge & practices related to hysterectomy (p= 0.000*).The study group received adequate and significant preoperative counseling concerning hysterectomy, in terms of clearing up misconceptions, alleviating fear and physical preparation of the patient compared to those in the control group. The program had resulted in an average reduction in length of stay of 3.29±1.56 days and a decrease in complications by as much as 5%. Meanwhile, earlier return of gastrointestinal function (65%), mild to moderate pain scores (25% to 45%), early ambulation (80%) as well as early removal of the urinary catheter (2.2±0.8 day), were also observed. It also significantly improved patient's satisfaction. Conclusion, the prevalence of hysterectomy was 33.5% with abdominal hysterectomy constituting the most common type. The intervention nursing program resulted in shorter hospital stay, less postoperative pain and an increase of patients' satisfaction compared to the control group. Recommendation: Maternity nurses should use these guidelines to help integrate existing knowledge into practice, align perioperative care, and encourage future investigations of optimal preoperative and postoperative care for patients undergoing gynecologic/oncology operations.