Background: The mother engages to develop a comprehensive care plan specific to the needs of the child with nephrotic syndrome. The mother seeks to understand the child with respect to health status, abilities, and priorities. Aim: This study aim was to a assess mother's care for children with nephrotic syndrome at home. Design: Descriptive research design was utilized in this study. Setting: The urologic pediatric outpatient clinic in Pediatric Ain Shams university hospital. Sample: a purposive sample of school age children equal 100 children. Tool: interviewing questionnaire consisted of children and caregivers socio-demographic characteristic, child's past and present medical history, caregivers' knowledge and practice about nephrotic syndrome. Results: more than one third of the mothers of children with nephrotic syndrome have unsatisfactory knowledge level and the vast majority of them not done correctly care to their children. Also, there were statistically significant differences between mothers' knowledge and demographic characteristics of the mothers except occupation and their residence. Conclusion: the mothers of nephrotic child had poor caring for their children with no statistically significant differences between mothers' care and demographic characteristics of the mothers except number of children in the family and their residence; also there was strong positive correlation between mothers' knowledge and their practice. Recommendation: conducting educational classes for the mothers and their children about nephrotic syndrome especially newly diagnosed patients at urology pediatric outpatient clinic.