The clinical experience is frequently perceived as a stressor in clinical education by nursing students. This study is a quasi-experimental aimed to assess the stressors related to students' training in pediatric critical care settings (PCCSs), study the factors affecting students' training in PCCSs, design, implement and evaluate nursing intervention based on needs assessment of the students. This study was conducted at Pediatric Nursing Departments inboth Faculty of Nursing/Ain Shams and El-Fayoum Universities. The study involved 120 purposive students in the 3rd academic year/ Pediatric Nursing Department regardless their age, residence and socioeconomic standards. Tools of the data collection were used pre and post nursing intervention namely, pre designed interviewing questionnaire (to assess the students' characteristics, data about factors that affect the students' training in PCCSs as well, the stressors perceived by the students in their training and the students' knowledge related to their training in PCCSs), Hamilton Rating Scale (to assess the students' anxiety level). The main results of the study showed that, there was a statistical significant difference between the students' knowledge regarding to PCCSs and total stress level pre and post nursing intervention among the study group compared with the control group. The study concluded that, the application of nursing intervention reduce the students' stressors related to their training in pediatric critical care settings. The study recommended orientation program, identifying students' needs in the pediatric critical care settings and developing effective nursing interventions to reduce their stress