Background: Post lumbar puncture headache is the most common serious
complication resulting from lumbar punctures. There are interrelated factors can magnified
the incidence and severity of post lumbar puncture headache. Aim: This study aimed to
assess factors contributing to headache and its associated symptoms for post-lumbar
puncture patients. Design: A descriptive explorative design was utilized in the current study.
Setting: This study conducted in general surgery, orthopedic, gynecology and urology
departments at Beni-Suef University Hospital. Study subjects: Convenient sample of 80
patients included from the above-mentioned setting from both genders. Tools: (I) Lumbar
Puncture Interview Questionnaire: It include three parts: factors related to patients, factors
related to practitioner and lumbar puncture procedure. (II) Tension Headache Dairy: To
assess patients for post lumbar puncture headache and its associated symptoms. Results:
Revealed that more than half of studied subjects had post lumbar puncture headache and
there was significant relation between post lumbar puncture headache and age, gender,
educational level, past history of headache, needle diameter, and number of dural puncture
trails. Conclusion: overall, the study showed that there were interrelated factors affecting
on post lumbar puncture headache incidence that include non-modifiable factors related to
patients' characteristics as age, gender, past history of headache, pregnancy and past history
of previous lumbar puncture headache. While, there were modifiable factors related to
lumbar puncture procedure and practitioner experience that include needle diameter,
number of trails to enter subarachnoid space, amount of cerebrospinal fluid lost during
procedure. Recommendations: The study should be replicated on large sample size and in
different hospitals setting in order to generalize the results and figure out more factors
affecting the incidence of post lumbar puncture headache and its associated symptoms.