Background: Children undergoing cardiovascular surgery are exposed to many stresses due to their admission in the hospital these stressors are usually due to invasive procedures, physical stress, changing in their body image and social isolation. This leads to major psychological disturbance as anxiety and depression. Aim: The aim of this study was to assess the stressors and coping patterns of children undergoing cardiovascular surgery and their caregivers. Sample: descriptive study subject of 80 child and their caregivers, who divided into two equally matched groups' the study and control groups. Setting: This study was conducted at heart diseases and vascular surgeries department at Ain Shams hospitals affiliated to Ain Shams University. Tools for data collection: they consisted of questionnaire to assess of the study subjects (physical, psychological, social, and financial) stressors and coping behavior scale to measure their adaptive attitude The result: There as highly statistical significant difference between study and control groups as regards physical, psychological and social of items of Caregivers' stressors pre/post Conclusion: cardiovascular surgery imposes physical, psychological and social stressors upon the children undergoing cardiovascular surgery and their caregivers and coping patterns were adopted to deal with these stressors. It is recommended that, positively. Recommendations: the nurses should help caregivers and their children undergoing cardiovascular surgery to detect resources of stress and empower their coping patterns.