Objective: Fall is one of the major risks among different categories of patients including patient with neurological disorder who is at high risk of falling, which increasing their level of dependency. Nurses' roles in identifying the falling risk and barriers of patient safety became a vital need in order to alleviate those risks and improving patients' safety and to minimize this adverse event. Aims of the study are to: identify nurse's assessment of falling risk and barriers of patient safety measures among patients with neurological disorders. Research questions: can nurses identify falling risk among neurological patients with different conditions? Does nurses aware about the barriers of applying universal precautions and patients safety in different conditions? What are the interventions methods to overcome these barriers? Research design: A descriptive cross sectional research design was used. Setting: The study was conducted at center of psychiatric medicine and brain and neurology disease, Tanta University. Subjects: finite sample including, all nurses work in ICU and brain and neurology units (46 nurses out of 50) nurses. Tool: Two tools were used for data collection. Tool one "Nurses assessment of the factors affecting patient condition", tool two ""Prevention of fall" to assess. Results: there was a significant difference regarding insisting of patient to move as barriers of patient's safety. Conclusion: the present study finding concluded that: Lack of nurses' knowledge and practice in applying risk assessment of fall and universal precautions due to number of barriers including inadequate facilities and negligence of hospital management. Recommendations: application prevention of falling program by hospital management, and establish interdisciplinary team for training programs for staff nurses.