Aim of the study was to assess the effect of menopausal symptoms on women's quality of life. Design: A descriptive study design was carried out. Setting: The study was conducted at Benha University. Sampling: purposive sample included 200 menopausal women. Tools of data collection: interviewing questionnaire sheet, knowledge assessment sheet regarding menopause, menopausal rating scale sheet and quality of life assessment sheet. Results: the study results revealed that more than two third of the studied group had poor knowledge about menopause and of the studied group had moderate level of menopausal symptoms and there are a negative strong correlation between menopausal symptoms and quality of life. Conclusion: the present study revealed that women's quality of life affected negatively with menopausal symptoms and the majority of the studied group had average quality of life. Recommendation: design awareness program for women regarding menopausal symptoms and dealing with it.