Background: Effective management and organizational commitment are vital issue and any imbalance between them leads to many problems such as work stress, burnout, high rates of staff turnover, absenteeism, poor job satisfaction and low psychological wellbeing levels. Aim of the study: The aim of the current study was to assess the relationship between organizational commitment, burnout, and psychological wellbeing among staff nurses. Setting: The study was conducted at the inpatient departments of El-Abbassiya Governmental Hospital for Psychiatric and Mental Health affiliated to Ministry of Health, Cairo. Subjects: The sample included 220 staff nurses. Data collection tools: Data was collected using three tools namely, Organizational Commitment Questionnaire (OCQ), Maslach Burnout Inventory scale and Ryff's Psychological Wellbeing (PWB) scales. Results: the current study revealed that about half of the studied nurses had high organizational commitment, more than half of them had low burnout level, and the highest mean score for psychological wellbeing dimensions was regarding the positive relationship and purpose in life. Conclusion:  showed that there was a statistically significant positive correlation among all organizational commitment dimensions and the studied staff nurses' levels of burnout and psychological wellbeing levels. Recommendations: The study recommended providing various educational programs to improve nurse commitment and psychological wellbeing to retain nurses and minimize burnout.