Liver transplant recipients suffer from a chronic condition, which by itself entails risks and health problems, so they need to understand the transplantation process so as to change their living experience for better life post transplantation. The aim of this study was to The aim of this study was to assess the effect of health needs management program on liver transplant recipients' needs and their compliance to therapeutic regimen .Research design: A quasi experimental design was utilized to meet the aim of the study. Setting: The study was conducted in liver transplantation outpatient clinic at El Manial Cairo University hospital. Subjects: A purposive subjects of 40 patients post liver transplantation surgery from the liver transplantation outpatient clinic. Tools: A) Patient structured interviewing questionnaire to assess demographic characteristics among study subjects. B) Patients 'needs assessment tool to assess the following: 1. physical needs, 2. psychological needs, 3. social needs, 4. spiritual needs.5.educational needs C) Patients' compliance questionnaire. Results: there were statistically significant differences among study subjects between pre and post program implementation regarding physical, psychological, social and educational needs. Furthermore, there were highly statistically significant differences between pre and post program implementation phases regarding all items of compliance among study group subjects. Conclusion: this study concluded that health needs management program had a positive effect in improvement of overall physical, psychological, social and educational needs of the recipient a well as their compliance to the therapeutic regime post program implementation. Recommendation: Health care providers specially nurses should develop time specific education programs based on liver transplant recipients' educational needs at different post transplant times to maintain patients' compliance .