Persistent nausea and vomiting(hyperemesis gravidarum) in early pregnancy remains a significant health problem that result in negative side effects on women and their pregnancy This study aimed to assess psycho-social aspects related to development of hyperemesis gravidarum. Methods: A case control prospectivestudy was utilized in carrying out this study. The study was conducted at maternity high risk care departments at Mansoura University Hospitals for hyperemesis group& Antenatal Care Clinics at Mansoura University Obstetric and Gynecological Center for healthy group, each group included 50 women. Data were collected by four tools: tool I:structured interviewing questionnaire schedule, tool II: Index of Nausea, Vomiting and Retching (INVR), tool III: modified multidimensional scale of perceived social support and tool IV: The Arabic version of Beck Depression Inventory questionnaire. Results: It showed that there were no statistically significant differences in general characteristics among hyperemesis and healthy groups except for consanguinity, educational leveland income. Highly statistical significant differences were found in mean and standard deviation regarding nausea, vomiting and retching and total Rhodes index scores among the studied groups (p ≤ 0.05). Also there were highly statistically significant differences among hyperemesis and healthy groups regarding levels of depression as 32% of women suffered from extreme depression in hyperemesis group compared to 0% in healthy group. Conclusion: The study concluded that hyperemesis group suffered from psychosocial problems as depression and decreased social support than healthy group this related to negative effect of hyperemesis gravidarum.