Background: Sexual harassment is unwelcome sexual behavior as unwanted and unwelcome words, actions, gestures, symbols or behaviours of a sexual nature that make the target feel uncomfortable. Aim: The present study was carried out with the aim to assess the effectiveness of nursing supporting instructions toward sexual harassment related menstrual and psychological problems among female nursing students. Design: Quasi – experimental design was used in carrying out the study. Settings: The study was conducted at the Faculty of Nursing- Helwan University. Subjects: A purposive sample was used for conduction of this study. It included 228 nursing students. Data collection: The data was collected by using three tools, structured interview questionnaire, student stress scale and follow-up assessment tool. Results: Based on the current results, the entire sample of the studied students suffering from sexual harassment related menstrual (52%) and psychological (86%) problems. It also revealed that, there was noticeable improvement of their problems after utilizing the nursing supporting instructions. Conclusion: The study concluded that, nursing supporting instructions were highly effective toward sexual harassment related menstrual and psychosocial problems among female students. Recommendations: The study recommended integration of female students counseling at all levels of their education about this critical issue.